menu
Your Cart

ITM0520

ITM0520
  • Gene/Protein: LIMS1
  • Product Description: Immunotag™ Pinch-1 Monoclonal Antibody
368.0000
Price in reward points: 368

Available Options

Immunotag™ Pinch-1 Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein Pinch-1
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IF,FCM,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of human Pinch-1 expressed in E. Coli.
Specificity Pinch-1 Monoclonal Antibody detects endogenous levels of Pinch-1 protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name LIMS1
Accession No. P48059 Q99JW4
Alternate Names LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48
Description LIM zinc finger domain containing 1(LIMS1) Homo sapiens The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010],
Protein Expression Bone marrow,Fetal liver,Platelet,Renal cell carcinoma,
Subcellular Localization cytosol,plasma membrane,cell-cell junction,focal adhesion,protein complex,perinuclear region of cytoplasm,
Protein Function function:Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.,similarity:Contains 5 LIM zinc-binding domains.,subunit:Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts (via LIM zinc-binding 1) with ILK. Interacts with SH3/SH2 adapter NCK2.,tissue specificity:In most tissues, except in the brain.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish

Write a review

Note: HTML is not translated!
Bad Good
Captcha

CONNECT WITH US