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ITM0580

ITM0580
  • Catalog: ITM0580
  • Gene/Protein: SNAI2
  • Product Description: Immunotag™ SLUG Monoclonal Antibody
504.0000
Price in reward points: 504

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Immunotag™ SLUG Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein SLUG
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of human SLUG expressed in E. Coli.
Specificity SLUG Monoclonal Antibody detects endogenous levels of SLUG protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name SNAI2
Accession No. O43623 P97469
Alternate Names SNAI2; SLUG; SLUGH; Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2
Description snail family transcriptional repressor 2(SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Adherens_Junction,
Protein Expression Dermoid cancer,Uterus,
Subcellular Localization nuclear chromatin,nucleus,cytoplasm,
Protein Function disease:Defects in SNAI2 are a cause of neural tube defects (NTD).,disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.,function:Transcriptional repressor. Involved in the generation and migration of neural crest cells.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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