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ITM1018

ITM1018
  • Catalog: ITM1018
  • Gene/Protein: CAMK4
  • Product Description: Immunotag™ CaMKIV Monoclonal Antibody
438.0000
Price in reward points: 438

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Immunotag™ CaMKIV Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein CAMK4
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat,Chicken,Dog,Pig
Host Species Mouse
Immunogen Purified recombinant human CaMKIV protein fragments expressed in Ecoli
Specificity CaMKIV Monoclonal Antibody detects endogenous levels of CaMKIV protein.
Purification Affinity purification
Form Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Gene Name CAMK4
Accession No. Q16566 P08414 P13234
Alternate Names CAMK4; CAMK; CAMK-GR; CAMKIV; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR
Description calcium/calmodulin dependent protein kinase IV(CAMK4) Homo sapiens The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Calcium,Long-term potentiation,Neurotrophin,
Protein Expression Blood,Brain,Cerebellum,Lung,Thymus,
Subcellular Localization nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,extracellular exosome,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.,PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.,subunit:Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.,tissue specificity:Expressed in epithelial ovarian cancer tissue.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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