ITM1022
ITM1022
- Catalog: ITM1022
- Gene/Protein: CHRDL1
- Product Description: Immunotag™ CHRDL1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CHRDL1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human CHRDL1 protein fragments expressed in Ecoli |
| Specificity | CHRDL1 Monoclonal Antibody detects endogenous levels of CHRDL1 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | CHRDL1 |
| Accession No. | Q9BU40 Q920C1 Q76LD0 |
| Alternate Names | CHRDL1; NRLN1; Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin |
| Description | chordin like 1(CHRDL1) Homo sapiens This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009], |
| Protein Expression | Brain,Lung,Uterus, |
| Subcellular Localization | extracellular region, |
| Protein Function | function:Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.,induction:By hypoxia in retinal pericytes.,similarity:Contains 3 VWFC domains.,tissue specificity:Expressed in retinal pericytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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