ITM1026
ITM1026
- Catalog: ITM1026
- Gene/Protein: CYP7A1
- Product Description: Immunotag™ CYP7A1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CYP7A1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli. |
| Specificity | CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | CYP7A1 |
| Accession No. | P22680 Q64505 |
| Alternate Names | CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1 |
| Description | cytochrome P450 family 7 subfamily A member 1(CYP7A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010], |
| Cell Pathway/ Category | Primary bile acid biosynthesis,Steroid hormone biosynthesis,PPAR, |
| Protein Expression | Liver,Placenta, |
| Subcellular Localization | endoplasmic reticulum membrane,organelle membrane,intracellular membrane-bounded organelle, |
| Protein Function | catalytic activity:Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.,cofactor:Heme group.,online information:Cholesterol-7 alpha-hydroxylase entry,pathway:Lipid metabolism; bile acid biosynthesis.,similarity:Belongs to the cytochrome P450 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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