ITM1112
ITM1112
- Catalog: ITM1112
- Gene/Protein: CKMT1A/CKMT1B
- Product Description: Immunotag™ uMtCK Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | uMtCK |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Dog,Pig,Rabbit |
| Host Species | Mouse |
| Immunogen | Purified recombinant human uMtCK protein fragments expressed in Ecoli |
| Specificity | uMtCK Monoclonal Antibody detects endogenous levels of uMtCK protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | CKMT1A/CKMT1B |
| Accession No. | P12532 P30275 P25809 |
| Alternate Names | CKMT1A; CKMT; CKMT1B; CKMT; Creatine kinase U-type; mitochondrial; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK |
| Description | creatine kinase, mitochondrial 1B(CKMT1B) Homo sapiens Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mi |
| Cell Pathway/ Category | Arginine and proline metabolism, |
| Protein Expression | Cerebellum,Lung,PNS, |
| Subcellular Localization | mitochondrion,mitochondrial inner membrane,extracellular exosome, |
| Protein Function | catalytic activity:ATP + creatine = ADP + phosphocreatine.,function:Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.,miscellaneous:Mitochondrial creatine kinase binds cardiolipin.,similarity:Belongs to the ATP:guanido phosphotransferase family.,subunit:Exists as an octamer composed of four MTCK homodimers., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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