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ITM1203

ITM1203
  • Catalog: ITM1203
  • Gene/Protein: kdm1a
  • Product Description: Immunotag™ KDM1/LSD1 mouse mAb
405.0000
Price in reward points: 405

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Immunotag™ KDM1/LSD1 mouse mAb
Antibody Specification
Datasheet
Target Protein KDM1/LSD1
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,ICC,IP
Recommended Dilution wb 1:1000 icc 1:100
Concentration 1 mg/ml
Reactive Species Human,Monkey
Host Species Mouse
Immunogen Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.
Specificity This antibody detects endogenous levels of KDM1/LSD1 and does not cross-react with related proteins.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name kdm1a
Accession No. O60341 Q6ZQ88
Alternate Names Amine oxidase (flavin containing) domain 2;AOF2;BHC110;BRAF35 HDAC complex protein BHC110;BRAF35-HDAC complex protein BHC110;FAD binding protein BRAF35 HDAC complex, 110 kDa subunit;Flavin-containing amine oxidase domain-containing protein 2;KDM 1;KDM1;Kdm1a;KDM1A_HUMAN;LSD 1;LSD1;Lysine (K) specific demethylase 1;Lysine (K) specific demethylase 1A;Lysine specific histone demethylase 1;Lysine specific histone demethylase 1A;Lysine-specific histone demethylase 1A.
Description lysine demethylase 1A(KDM1A) Homo sapiens This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
Protein Expression Brain,Epithelium,Skin,Testis,
Subcellular Localization nuclear chromosome, telomeric region,nuclear chromatin,nucleus,nucleoplasm,transcription factor complex,protein complex,DNA repair complex,
Protein Function cofactor:FAD.,domain:The SWIRN domain may act as an anchor site for a histone tail.,function:Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis.,similarity:Belongs to the flavin monoamine oxidase family.,similarity:Contains 1 SWIRM domain.,subunit:Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR).,tissue specificity:Ubiquitously expressed.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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