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ITM1293

ITM1293
  • Catalog: ITM1293
  • Gene/Protein: adrbk1
  • Product Description: Immunotag™ GRK2 mouse mAb
405.0000
Price in reward points: 405

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Immunotag™ GRK2 mouse mAb
Antibody Specification
Datasheet
Target Protein GRK2
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution wb 1:500
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant human GRK2 protein fragments expressed in E.coli.
Specificity This antibody detects endogenous levels of GRK2 and does not cross-react with related proteins.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name adrbk1
Accession No. P25098 Q99MK8
Alternate Names ADRBK 1;ADRBK1;Adrenergic beta receptor kinase 1;Adrenergic beta receptor kinase 1; ARBK1_HUMAN;BARK 1;BARK;BARK1;Beta adrenergic receptor kinase 1;Beta ARK 1;Beta ARK1; Beta-adrenergic receptor kinase 1;Beta-ARK-1;FLJ16718;G Protein Coupled Receptor Kinase 2;G protein dependent receptor kinase 2;G-protein coupled receptor kinase 2;GRK 2;GRK2.
Description G protein-coupled receptor kinase 2(GRK2) Homo sapiens The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Chemokine,Endocytosis,
Protein Expression Blood,Platelet,PNS,Spleen,Testis,
Subcellular Localization cytoplasm,cytosol,plasma membrane,membrane,primary cilium,
Protein Function catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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