ITM1314
ITM1314
- Catalog: ITM1314
- Gene/Protein: aldh3a2
- Product Description: Immunotag™ Aldehyde dehydrogenase 10 mouse mAb
405.0000
Price in reward points: 405
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | ALDH 10 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | wb 1:1000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant human Aldehyde dehydrogenase 10 protein fragments expressed in E.coli. |
Specificity | This antibody detects endogenous levels of Aldehyde dehydrogenase 10 and does not cross-react with related proteins. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | aldh3a2 |
Accession No. | P51648 P47740 |
Alternate Names | Aldehyde dehydrogenase;Aldehyde dehydrogenase 10;Aldehyde dehydrogenase 3 family member A2;ALDH10;ALDH3A2;DKFZp686E23276;FALDH;Fatty aldehyde dehydrogenase;FLJ20851;Microsomal aldehyde dehydrogenase;OTTHUMP00000065799;OTTHUMP00000065800;OTTHUMP00000065801;SLS. |
Description | aldehyde dehydrogenase 3 family member A2(ALDH3A2) Homo sapiens Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,Arginine and proline metabolism,Histidine metabolism,Tryptophan metabolism,beta-Alanine metabolism,Glycerolipid metabolism,Pyruvate metabolism,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation, |
Protein Expression | Adrenal gland,Brain,Liver,Skin,Testis,Trachea, |
Subcellular Localization | mitochondrial inner membrane,peroxisome,peroxisomal membrane,endoplasmic reticulum membrane,integral component of membrane,intracellular membrane-bounded organelle,extracellular exosome, |
Protein Function | catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS) [MIM:270200]. SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.,function:Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.,similarity:Belongs to the aldehyde dehydrogenase family., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |