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ITM1514

ITM1514
  • Catalog: ITM1514
  • Gene/Protein: arrb1
  • Product Description: Immunotag™ β-Arrestin 1 mouse mAb
405.0000
Price in reward points: 405

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Immunotag™ β-Arrestin 1 mouse mAb
Antibody Specification
Datasheet
Target Protein β-Arrestin 1
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution wb dilution 1:500
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Recombinant human β-Arrestin 1 protein.
Specificity This antibody detects endogenous levels of β-Arrestin 1 and does not cross-react with related proteins.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name arrb1
Accession No. P49407 Q8BWG8
Alternate Names ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
Description arrestin beta 1(ARRB1) Homo sapiens Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Chemokine,Endocytosis,
Protein Expression Brain,Peripheral blood,Uterus,
Subcellular Localization Golgi membrane,chromatin,nucleus,nucleoplasm,cytoplasm,lysosomal membrane,cytosol,heterotrimeric G-protein complex,plasma membrane,clathrin-coated pit,postsynaptic density,basolateral plasma membrane,cytoplasmic vesicle membr
Protein Function function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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