ITM1519
ITM1519
- Catalog: ITM1519
- Gene/Protein: tlr7
- Product Description: Immunotag™ Toll-like Receptor 7 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Toll-like Receptor 7 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb dilution 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Transfected |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Toll-like Receptor protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of Toll-like Receptor and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | tlr7 |
| Accession No. | Q9NYK1 P58681 |
| Alternate Names | PRO285; TLR 7; Tlr7; TLR7_HUMAN ; Toll like receptor 7 ; Toll-like receptor 7; UNQ248. |
| Description | toll like receptor 7(TLR7) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Toll_Like, |
| Protein Expression | Placenta,Synovial membrane tissue,Testis, |
| Subcellular Localization | Golgi membrane,cytoplasm,lysosome,endosome,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,integral component of plasma membrane,endosome membrane,integral component of membrane,early phagosome,endolysosome |
| Protein Function | function:Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 27 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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