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ITM3056

ITM3056
ITM3056-2
ITM3056-4
ITM3056-6
ITM3056-3
ITM3056-5
ITM3056
ITM3056-2
ITM3056-4
ITM3056-6
ITM3056-3
ITM3056-5
ITM3056
  • Catalog: ITM3056
  • Gene/Protein: KRT16
  • Product Description: Immunotag™ CK16 Monoclonal Antibody(6F6)
405.0000
Price in reward points: 405

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Immunotag™ CK16 Monoclonal Antibody(6F6)
Antibody Specification
Datasheet
Target Protein CK16 (6F6)
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application IHC-P,IF
Recommended Dilution IHC 1:200 IF 1:50-200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Mouse
Immunogen Synthetic Peptide of CK16
Specificity The antibody detects endogenous CK16 proteins.
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Form PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene Name KRT16
Accession No. P08779 Q9Z2K1
Alternate Names KRT16; KRT16A; Keratin, type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
Description keratin 16(KRT16) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008],
Protein Expression Keratinocyte,Mammary cancer,Skin,
Subcellular Localization nucleus,cytoskeleton,intermediate filament,extracellular exosome,
Protein Function disease:Defects in KRT16 are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.,disease:Defects in KRT16 are a cause of unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]. UPVN is characterized by a localized thickening of the skin in parts of the right palm and the right sole.,disease:Defects in KRT16 are the cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.,disease:KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers. Interacts with TCHP. Interacts with TRADD.,tissue specificity:Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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