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ITM3223

ITM3223
ITM3223
ITM3223
  • Gene/Protein: PTGS1
  • Product Description: Immunotag™ COX1 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ COX1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein COX1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution WB: 1:1000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthetic Peptide of COX1
Specificity The antibody detects endogenous COX1 proteins.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen
Form PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene Name PTGS1
Accession No. P23219 P22437 Q63921
Alternate Names PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
Description prostaglandin-endoperoxide synthase 1(PTGS1) Homo sapiens This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Cell Pathway/ Category Arachidonic acid metabolism,
Protein Expression Brain,Lung fibroblast,Platelet,
Subcellular Localization photoreceptor outer segment,nucleus,cytoplasm,endoplasmic reticulum membrane,Golgi apparatus,organelle membrane,intracellular membrane-bounded organelle,extracellular exosome,
Protein Function catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,function:May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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