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ITM3224

ITM3224
ITM3224
ITM3224
  • Catalog: ITM3224
  • Gene/Protein: PTGS2
  • Product Description: Immunotag™ COX2 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ COX2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein COX2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution WB: 1:1000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthetic Peptide of COX2
Specificity The antibody detects endogenouse COX2 proteins.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen
Form PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene Name PTGS2
Accession No. P35354 Q05769 P35355
Alternate Names PTGS2; COX2; Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
Description prostaglandin-endoperoxide synthase 2(PTGS2) Homo sapiens Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],
Cell Pathway/ Category Arachidonic acid metabolism,VEGF,Pathways in cancer,Small cell lung cancer,
Protein Expression Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe
Subcellular Localization nucleus,cytoplasm,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,caveola,organelle membrane,neuron projection,protein complex,
Protein Function catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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