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ITM3255

ITM3255
ITM3255
ITM3255
  • Gene/Protein: KRT18
  • Product Description: Immunotag™ CK18 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ CK18 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CK18
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution WB: 1:1000-2000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Recombinant Protein of Keratin type I cytoskeletal 18
Specificity The antibody detects endogenous Cytokeratin 18 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen
Form PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene Name KRT18
Accession No. P05783 P05784 Q5BJY9
Alternate Names KRT18; CYK18; PIG46; Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
Description keratin 18(KRT18) Homo sapiens KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Pathogenic Escherichia coli infection,
Protein Expression Cervix,Colon,Colon carcinoma,Epithelium,Liver,Pancreas,Placenta,Uterus,Vulva,
Subcellular Localization nucleolus,cytoplasm,microtubule organizing center,intermediate filament,cell-cell adherens junction,centriolar satellite,keratin filament,perinuclear region of cytoplasm,extracellular exosome,cell periphery,
Protein Function disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.,tissue specificity:Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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