ITM3347
ITM3347
- Catalog: ITM3347
- Gene/Protein: PGC
- Product Description: Immunotag™ PEPC (Phospho Ser15) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PEPC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | WB: 1:1000-2000 |
| Concentration | 1 mg/ml |
| Reactive Species | Plants |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of PEPC (Phospho Ser15) |
| Specificity | The antibody detects endogenous PEPC (Phospho Ser15) protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | PGC |
| Accession No. | P20142 Q9D7R7 P04073 |
| Alternate Names | PGC; Gastricsin; Pepsinogen C |
| Description | progastricsin(PGC) Homo sapiens This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009], |
| Protein Expression | Brain,Liver,Placenta,Stomach, |
| Subcellular Localization | extracellular space,extracellular exosome, |
| Protein Function | catalytic activity:More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.,function:Hydrolyzes a variety of proteins.,similarity:Belongs to the peptidase A1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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