ITM3392
ITM3392
- Catalog: ITM3392
- Gene/Protein: TLR6
- Product Description: Immunotag™ TLR6 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TLR6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC: 1:200-500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Recombinant Protein of TLR6 |
| Specificity | The antibody detects endogenous TLR6 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | TLR6 |
| Accession No. | Q9Y2C9 Q9EPW9 |
| Alternate Names | Toll-like receptor 6; CD286 |
| Description | toll like receptor 6(TLR6) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011], |
| Cell Pathway/ Category | Toll_Like, |
| Protein Expression | PCR rescued clones,Placenta, |
| Subcellular Localization | Golgi apparatus,plasma membrane,integral component of plasma membrane,integral component of membrane,phagocytic vesicle membrane,Toll-like receptor 2-Toll-like receptor 6 protein complex,membrane raft, |
| Protein Function | function:Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 13 LRR (leucine-rich) repeats.,subunit:Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains.,tissue specificity:Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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