ITM3514
ITM3514
- Catalog: ITM3514
- Gene/Protein: PPIB
- Product Description: Immunotag™ Cyclophilin B Monoclonal Antibody(1B3)
405.0000
Price in reward points: 405
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | CyclophIL-in B (1B3) |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p |
Recommended Dilution | WB 1:1000-2000, IHC 1:100-200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Rat,Mouse |
Host Species | Mouse |
Immunogen | Synthetic Peptide of Cyclophilin B |
Specificity | Cyclophilin B protein detects endogenous levels of Cyclophilin B |
Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | PPIB |
Accession No. | P23284 P24369 P24368 |
Alternate Names | PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
Description | peptidylprolyl isomerase B(PPIB) Homo sapiens The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009], |
Protein Expression | Brain,Fetal brain cortex,Prostate,Skin, |
Subcellular Localization | nucleus,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,focal adhesion,membrane,macromolecular complex,endoplasmic reticulum chaperone complex,melanosome,perinuclear region of cytoplasm,extracellular |
Protein Function | catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |