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ITM3520

ITM3520
ITM3520-2
ITM3520
ITM3520-2
ITM3520
  • Catalog: ITM3520
  • Gene/Protein: PRKAA1
  • Product Description: Immunotag™ AMPK α1 Monoclonal Antibody(5G11)
405.0000
Price in reward points: 405

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Immunotag™ AMPK α1 Monoclonal Antibody(5G11)
Antibody Specification
Datasheet
Target Protein AMPK α1 (5G11)
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p
Recommended Dilution WB 1:1000-2000, IHC 1:50-100
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Mouse
Immunogen Synthetic Peptide of AMPK α1
Specificity AMPK α1 protein detects endogenous levels of AMPK α1
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PRKAA1
Accession No. Q13131 Q5EG47 P54645
Alternate Names PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1
Description protein kinase AMP-activated catalytic subunit alpha 1(PRKAA1) Homo sapiens The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Regulation of autophagy,mTOR,Insulin_Receptor,Adipocytokine,Hypertrophic cardiomyopathy (HCM),
Protein Expression Brain,Intestine,Liver,Mammary gland,Platelet,Testis
Subcellular Localization intracellular,nucleus,nucleoplasm,cytoplasm,cytosol,apical plasma membrane,nucleotide-activated protein kinase complex,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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