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ITM3521

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  • Gene/Protein: NFKBIB
  • Product Description: Immunotag™ IκB β Monoclonal Antibody(1F3)
294.0000
Price in reward points: 294

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Immunotag™ IκB β Monoclonal Antibody(1F3)
Antibody Specification
Datasheet
Target Protein IκB- β (1F3)
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application IHC-P,IF
Recommended Dilution IHC 1:200 IF 1:50-200
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Mouse
Immunogen Recombinant Protein of IκB β
Specificity IκB β protein detects endogenous levels of IκB β
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name NFKBIB
Accession No. Q15653 Q60778 Q9JIA3
Alternate Names NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9
Description NFKB inhibitor beta(NFKBIB) Homo sapiens The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011],
Cell Pathway/ Category Chemokine,NOD-like receptor,RIG-I-like receptor,Cytosolic DNA-sensing pathway,T_Cell_Receptor,B_Cell_Antigen,Neurotrophin,Adipocytokine,
Protein Expression Brain,Cervix carcinoma,Pancreas,Uterus,
Subcellular Localization nucleus,cytosol,
Protein Function function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.,PTM:Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 6 ANK repeats.,subunit:Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.,tissue specificity:Expressed in all tissues examined.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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