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ITM3541

ITM3541
ITM3541
ITM3541
  • Gene/Protein: CCKBR
  • Product Description: Immunotag™ CCKBR Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ CCKBR Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CCKBR
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution WB 1:1000-2000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthetic Peptide of CCKBR
Specificity CCKBR protein(A214) detects endogenous levels of CCKBR
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CCKBR
Accession No. P32239 P56481 P30553
Alternate Names CCKBR; CCKRB; Gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; Cholecystokinin-2 receptor; CCK2-R
Description cholecystokinin B receptor(CCKBR) Homo sapiens This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015],
Cell Pathway/ Category Calcium,Neuroactive ligand-receptor interaction,
Protein Expression Brain,Colon cancer,Fetal brain,Lung fibroblast,Pancreatic cancer,Peripheral
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,
Protein Function function:Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may regulate cancer cell proliferation via a gastrin-independent mechanism.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line H510, at lower levels in H345, H69 and GLC28, not expressed in GLC19. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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