ITM3550
ITM3550
- Catalog: ITM3550
- Gene/Protein: GABRA2
- Product Description: Immunotag™ GABA A Receptor α2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GABA A Receptor α2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB 1:1000-2000, IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of GABA A Receptor α2 |
| Specificity | GABA A Receptor α2 protein(A224) detects endogenous levels of GABA A Receptor α2 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GABRA2 |
| Accession No. | P47869 P26048 P23576 |
| Alternate Names | Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) |
| Description | gamma-aminobutyric acid type A receptor alpha2 subunit(GABRA2) Homo sapiens GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Amygdala,Brain, |
| Subcellular Localization | plasma membrane,integral component of membrane,cell junction,integral component of synaptic vesicle membrane,axon,dendrite,chloride channel complex,neuronal cell body,synapse,postsynaptic membrane,inhibitory |
| Protein Function | function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,polymorphism:Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [MIM:103780].,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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