ITM3567
ITM3567
- Catalog: ITM3567
- Gene/Protein: KCNN4
- Product Description: Immunotag™ KCNN4 (SK4) Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KCNN4 (SK4) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB 1:1000-2000, IHC 1:50-100 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of KCNN4 (SK4) |
| Specificity | KCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4) |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KCNN4 |
| Accession No. | O15554 O89109 Q9QYW1 |
| Alternate Names | KCNN4; IK1; IKCA1; KCA4; SK4; Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel |
| Description | potassium calcium-activated channel subfamily N member 4(KCNN4) Homo sapiens The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008], |
| Protein Expression | Lymph node,Myometrium,Pancreas,Placenta,Prostate, |
| Subcellular Localization | plasma membrane,voltage-gated potassium channel complex,integral component of membrane,vesicle, |
| Protein Function | function:Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.,induction:Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.,tissue specificity:Widely expressed in non-excitable tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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