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ITM3603

ITM3603
ITM3603-2
ITM3603
ITM3603-2
ITM3603
  • Gene/Protein: PPARD NR1C2 PPARB
  • Product Description: Immunotag™ PPAR Delta mouse Monoclonal Antibody(1D7)
294.0000
Price in reward points: 294

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Immunotag™ PPAR Delta mouse Monoclonal Antibody(1D7)
Antibody Specification
Datasheet
Target Protein PPAR Delta (1D7)
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application IHC-p
Recommended Dilution IHC 1:100-200
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Mouse
Immunogen Recombinant Protein of PPAR Delta of PPAR Delta
Specificity PPAR Delta protein detects endogenous levels of PPAR Delta
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PPARD NR1C2 PPARB
Accession No. Q03181 P35396
Alternate Names Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
Description peroxisome proliferator activated receptor delta(PPARD) Homo sapiens This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this
Cell Pathway/ Category PPAR,WNT,WNT-T CELLPathways in cancer,Acute myeloid leukemia,
Protein Expression Placenta,
Subcellular Localization nuclear chromatin,nucleus,nucleoplasm,
Protein Function function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand.,online information:Peroxisome proliferator-activated receptor entry,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer with the retinoid X receptor.,tissue specificity:Ubiquitous with maximal levels in placenta and skeletal muscle.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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