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  • Gene/Protein: MAPK10 JNK3 JNK3A PRKM10 SAPK1B
  • Product Description: Immunotag™ JNK3 Rabbit Polyclonal Antibody
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Immunotag™ JNK3 Rabbit Polyclonal Antibody
Antibody Specification
Target Protein JNK3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p
Recommended Dilution IHC-p 1:50-300
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Recombinant Protein of JNK3
Specificity The antibody detects endogenous JNK3 protein
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Accession No. P53779 Q61831 P49187
Alternate Names Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Description mitogen-activated protein kinase 10(MAPK10) Homo sapiens The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015],
Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,ErbB_HER,WNT,WNT-T CELLFocal adhesion,Toll_Like,NOD-like receptor,RIG-I-like receptor,Fc epsilon RI,Neurotrophin,Insulin_Receptor,GnRH,Progesterone-mediated oocyte maturation,Adipocytokine,Type II diabetes mellitus,Epithelial cell signaling in Helicobacter pylori infection,Pathways in cancer,Colorectal cancer,Pancreatic cancer,
Protein Expression Brain,Caudate nucleus,Hippocampus,Testis,Uterus,
Subcellular Localization intracellular,nucleoplasm,cytoplasm,mitochondrion,cytosol,plasma membrane,
Protein Function A similar low level of binding to substrates is observed for isoform alpha-1 and isoform alpha-2. However, there is no correlation between binding and phosphorylation, which is achieved about at the same efficiency by all isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,disease:A chromosomal rearrangement involving MAPK10 is a cause of epileptic encephalopathy Lennox-Gastaut type [MIM:606369]. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity.,mass spectrometry: PubMed:10715136,PTM:Dually phosphorylated on Thr-221 and Tyr-223, which activates the enzyme. Weakly autophosphorylated on threonine and tyrosine residues in vitro.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9.,tissue specificity:Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet

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