ITM6037
ITM6037
- Catalog: ITM6037
- Gene/Protein: KRT20
- Product Description: Immunotag™ Cytokeratin 20 (ABT-Ck20) mouse mAb
490.0000
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Antibody Specification | |
Datasheet | |
Target Protein | CK-20 (5G1) |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p |
Recommended Dilution | IHC-p 1:100-500 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Synthesized peptide derived from human Cytokeratin 20 |
Specificity | This antibody detects endogenous levels of human Cytokeratin 20 |
Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | KRT20 |
Accession No. | P35900 |
Alternate Names | Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT) |
Description | keratin 20(KRT20) Homo sapiens The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008], |
Protein Expression | Intestine,Small intestine, |
Subcellular Localization | Cytoplasmic, Membranous |
Protein Function | developmental stage:First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury.,PTM:Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Associates with KRT8.,tissue specificity:Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |