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ITM6060

ITM6060
  • Catalog: ITM6060
  • Gene/Protein: GAST GAS
  • Product Description: Immunotag™ Gastrin (ABT-GAST) mouse mAb
490.0000
Price in reward points: 490

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Immunotag™ Gastrin (ABT-GAST) mouse mAb
Antibody Specification
Datasheet
Target Protein Gastrin (AS1A17)
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application IHC-p
Recommended Dilution IHC-p 1:100-500
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Synthesized peptide derived from human Gastrin
Specificity This antibody detects endogenous levels of human Gastrin
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GAST GAS
Accession No. P01350
Alternate Names Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)]
Description gastrin(GAST) Homo sapiens Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008],
Protein Expression Gastric mucosa,
Subcellular Localization Cytoplasmic
Protein Function function:Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.,online information:Gastrin entry,PTM:Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.,PTM:Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.,similarity:Belongs to the gastrin/cholecystokinin family.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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