ITN0019
ITN0019
- Catalog: ITN0019
- Gene/Protein: DAG1
- Product Description: Immunotag™ DAG1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DAG1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 830-910 |
| Specificity | DAG1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DAG1 |
| Accession No. | Q14118 Q62165 |
| Description | dystroglycan 1(DAG1) Homo sapiens This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015], |
| Cell Pathway/ Category | ECM-receptor interaction,Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy,Viral myocarditis, |
| Protein Expression | Muscle,Placenta,Skeletal muscle, |
| Subcellular Localization | extracellular region,basement membrane,extracellular space,nucleoplasm,cytoplasm,cytosol,cytoskeleton,plasma membrane,cell-cell adherens junction,focal adhesion,cell outer membrane,dystrophin-associated glycoprotein complex,d |
| Protein Function | function:Forms part of the dystrophin-associated protein complex (DAPC) which may link the cytoskeleton to the extracellular matrix. Alpha-dystroglycan functions as a laminin receptor. Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into peripheral nerve Schwann cells.,online information:Dystroglycan entry,similarity:Contains 1 peptidase S72 domain.,subunit:Interacts with SGCD (By similarity). Interacts with AGR2 and AGR3.,tissue specificity:Expressed in a variety of fetal and adult tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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