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ITN0029

ITN0029
  • Gene/Protein: RGS19 GAIP GNAI3IP
  • Product Description: Immunotag™ RGS19 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ RGS19 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein RGS19
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 90-170
Specificity RGS19 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name RGS19 GAIP GNAI3IP
Accession No. P49795 Q9CX84 O70521
Description regulator of G-protein signaling 19(RGS19) Homo sapiens G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008],
Protein Expression Blood,Brain,Placenta,Testis,
Subcellular Localization Golgi apparatus,heterotrimeric G-protein complex,cytoplasmic microtubule,brush border,cell cortex,postsynaptic density,membrane,cytoplasmic, membrane-bounded vesicle,clathrin-coated vesicle,beta-catenin destruction complex,
Protein Function function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:Phosphorylated, mainly on serine residues.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIPC PDZ domain.,tissue specificity:Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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