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ITN0118

ITN0118
  • Gene/Protein: PCBP1
  • Product Description: Immunotag™ PCBP1 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ PCBP1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PCBP1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 30-110
Specificity PCBP1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PCBP1
Accession No. Q15365 P60335
Description poly(rC) binding protein 1(PCBP1) Homo sapiens This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. Th
Cell Pathway/ Category Spliceosome,
Protein Expression Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Lung,Lymphocyte,Skin
Subcellular Localization nucleoplasm,cytoplasm,cell-cell adherens junction,membrane,intracellular ribonucleoprotein complex,intracellular membrane-bounded organelle,extracellular exosome,
Protein Function function:Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.,PTM:Phosphorylated; lowers poly(rC)-binding activity.,similarity:Contains 3 KH domains.,subcellular location:Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.,tissue specificity:Abundantly expressed in skeletal muscle, thymus and peripheral blood leucocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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