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ITN0186

ITN0186
  • Catalog: ITN0186
  • Gene/Protein: CYP51A1 CYP51
  • Product Description: Immunotag™ CP51A Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CP51A Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CP51A
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 210-290
Specificity CP51A Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CYP51A1 CYP51
Accession No. Q16850 Q8K0C4 Q64654
Description cytochrome P450 family 51 subfamily A member 1(CYP51A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Cell Pathway/ Category Steroid biosynthesis,
Protein Expression Bladder,Brain,Liver,
Subcellular Localization endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,membrane,integral component of membrane,organelle membrane,intracellular membrane-bounded organelle,
Protein Function catalytic activity:Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.,cofactor:Heme group.,function:Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.,pathway:Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostrate, liver, kidney and lung.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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