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ITN0207

ITN0207
  • Gene/Protein: IL10RB CRFB4 D21S58 D21S66
  • Product Description: Immunotag™ I10R2 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ I10R2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein I10R2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 240-320
Specificity I10R2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name IL10RB CRFB4 D21S58 D21S66
Accession No. Q08334 Q61190
Description interleukin 10 receptor subunit beta(IL10RB) Homo sapiens The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Cytokine-cytokine receptor interaction,Jak_STAT,
Protein Expression Fetal brain,Kidney,Synovial membrane tissue,
Subcellular Localization plasma membrane,integral component of membrane,interleukin-28 receptor complex,extracellular exosome,
Protein Function disease:Defects in IL10RB are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,function:Receptor for IL10 and IL22. Serves as an accessory chain essential for the active IL10 receptor complex and to initiate IL10-induced signal transduction events.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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