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  • Gene/Protein: IGF2BP1 CRDBP VICKZ1 ZBP1
  • Product Description: Immunotag™ IF2B1 Polyclonal Antibody
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Immunotag™ IF2B1 Polyclonal Antibody
Antibody Specification
Target Protein IF2B1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 10-90
Specificity IF2B1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Accession No. Q9NZI8 O88477 Q8CGX0
Description insulin like growth factor 2 mRNA binding protein 1(IGF2BP1) Homo sapiens This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],
Protein Expression Epithelium,
Subcellular Localization nucleus,cytoplasm,cytosol,cytoplasmic stress granule,lamellipodium,filopodium,axon,growth cone,intracellular ribonucleoprotein complex,dendritic spine,perinuclear region of cytoplasm,CRD-mediated
Protein Function domain:The third and fourth KH domains encompasse the protein dimerization motif and are necessary and sufficient for RNA binding. The KH domains are important for granule formation and localization. Contains two nuclear export signals, situated within the second and fourth KH domains.,function:RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC and CD44 mRNAs and stabilizes these mRNAs. Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their localizations. Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1. Binds to the coding sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to beta-catenin signaling. Binding to RNA employs a cooperative, sequential mechanism of homo- or heterodimerisation. Also involved in growth or survival of lung-cancer cells. Protects the MYC and MDR-1 mRNAs from cleavage by a endoribonuclease, thus prolonging their stabilities (By similarity). Binds to the 3'-UTR axonal localization signal (ALS) of TAU mRNA (By similarity). Binds to a conserved 54-nucleotide element in the 3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to synaptic activity.,induction:Up-regulated in response to beta-catenin activation.,PTM:Phosphorylated. Phosphorylation may influence mRNA translation.,similarity:Belongs to the RRM IMP/VICKZ family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,similarity:Contains 4 KH domains.,subcellular location:Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia. Colocalized with CD44 mRNA in RNP granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). Present in the form of granules and into F-actin-rich protrusion of dendrites, spines and subsynaptic sites (By similarity). Colocalizes with beta-actin mRNA in dendrites and spines (By similarity). Exhibited rapid, bidirectional movements in dendrites and spines (By similarity). Neuronal depolarization by KCl induces its rapid efflux from the cell body into dendrites.,subunit:Can form homo- and heterodimers with IGF2BP1 or IGF2BP3. Associates with mRNP complex. Found in a RNP granule complex with FMR1. Interacts with FMR1. Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts through the third and fourth KH domains with PABPC1 in a RNA-independent manner. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Interacts with ELAVL4 in a RNA-dependent manner (By similarity). Associates with microtubules and polysomes.,tissue specificity:Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary, gonocytes of testis, oocytes, spermatogonia and semen (at protein level). Expressed in testicular and lung cancer (at protein level). Expressed in kidney, prostate, trachea, testis and lung cancer.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet

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