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ITN0581

ITN0581
  • Gene/Protein: CP
  • Product Description: Immunotag™ CERU Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ CERU Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CERU
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity CERU Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CP
Accession No. P00450 Q61147 P13635
Description ceruloplasmin(CP) Homo sapiens The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012],
Cell Pathway/ Category Porphyrin and chlorophyll metabolism,
Protein Expression Bile,Bone marrow,Donated clones,Liver,Plasma,
Subcellular Localization extracellular region,extracellular space,cell,lysosomal membrane,extracellular exosome,blood microparticle,
Protein Function catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,cofactor:Binds 6 copper ions per monomer.,disease:Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.,disease:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.,function:Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.,online information:Ceruloplasmin entry,similarity:Belongs to the multicopper oxidase family.,similarity:Contains 3 F5/8 type A domains.,similarity:Contains 6 plastocyanin-like domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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