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ITN0619

ITN0619
  • Catalog: ITN0619
  • Gene/Protein: CNTNAP1 CASPR NRXN4
  • Product Description: Immunotag™ CNTP1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CNTP1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CNTP1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity CNTP1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CNTNAP1 CASPR NRXN4
Accession No. P78357 O54991 P97846
Description contactin associated protein 1(CNTNAP1) Homo sapiens The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009],
Cell Pathway/ Category Cell adhesion molecules (CAMs),
Protein Expression Neuroblastoma,
Subcellular Localization integral component of plasma membrane,voltage-gated potassium channel complex,integral component of membrane,paranode region of axon,myelin sheath,
Protein Function function:Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.,similarity:Belongs to the neurexin family.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 2 EGF-like domains.,similarity:Contains 4 laminin G-like domains.,subunit:Interacts with contactin in cis form.,tissue specificity:Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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