ITN0691
ITN0691
- Gene/Protein: TRIM63 IRF MURF1 RNF28 SMRZ
- Product Description: Immunotag™ TRI63 Polyclonal Antibody
280.0000
Price in reward points: 294
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TRI63 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TRI63 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TRIM63 IRF MURF1 RNF28 SMRZ |
| Accession No. | Q969Q1 Q38HM4 Q91Z63 |
| Description | tripartite motif containing 63(TRIM63) Homo sapiens This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012], |
| Protein Expression | Iris,Skeletal muscle,Skin, |
| Subcellular Localization | nucleus,cytoplasm,microtubule,Z disc,M band, |
| Protein Function | caution:It is uncertain whether Met-1 or Met-14 is the initiator.,developmental stage:Expressed throughout all developmental stages.,domain:The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.,function:E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.,pathway:Protein modification; protein ubiquitination.,sequence caution:Sequencing errors.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 COS domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.,subunit:Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE.,tissue specificity:Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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