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ITN0693

ITN0693
  • Gene/Protein: ZNRF1 NIN283
  • Product Description: Immunotag™ ZNRF1 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ ZNRF1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein ZNRF1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity ZNRF1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name ZNRF1 NIN283
Accession No. Q8ND25 Q91V17
Description zinc and ring finger 1(ZNRF1) Homo sapiens This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012],
Protein Expression Lung,Testis,
Subcellular Localization lysosome,endosome,cytosol,membrane,cell junction,synaptic vesicle membrane,
Protein Function domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin-protein ligase activity.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Associated with synaptic vesicle membranes in neurons.,tissue specificity:Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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