ITN0706
ITN0706
- Catalog: ITN0706
- Gene/Protein: HSD17B12
- Product Description: Immunotag™ DHB12 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DHB12 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DHB12 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HSD17B12 |
| Accession No. | Q53GQ0 O70503 Q6P7R8 |
| Description | hydroxysteroid 17-beta dehydrogenase 12(HSD17B12) Homo sapiens This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011], |
| Cell Pathway/ Category | Steroid hormone biosynthesis,Androgen and estrogen metabolism,Biosynthesis of unsaturated fatty acids, |
| Protein Expression | B-cell lymphoma,Brain,Liver,Pancreas,Thyroid, |
| Subcellular Localization | proteinaceous extracellular matrix,endoplasmic reticulum membrane,integral component of membrane, |
| Protein Function | catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.,pathway:Lipid metabolism; fatty acid biosynthesis.,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.,tissue specificity:Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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