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ITN0737

  • Gene/Protein: GAS2
  • Product Description: Immunotag™ GAS2 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITN0737

Immunotag™ GAS2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GAS2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity GAS2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name GAS2
Accession No. O43903 P11862
Description growth arrest specific 2(GAS2) Homo sapiens The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009],
Protein Expression Brain,Kidney,Skeletal muscle,
Subcellular Localization cytosol,cytoskeleton,actin filament,membrane,
Protein Function developmental stage:Specifically expressed at growth arrest.,function:May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.,PTM:Cleaved, during apoptosis, on a specific aspartic residue by caspases.,PTM:Phosphorylated on serine residues during the G0-G1 transition phase.,similarity:Belongs to the GAS2 family.,similarity:Contains 1 CH (calponin-homology) domain.,subcellular location:Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.,tissue specificity:Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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