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ITN0758

ITN0758
  • Catalog: ITN0758
  • Gene/Protein: GNL3 E2IG3 NS
  • Product Description: Immunotag™ GNL3 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ GNL3 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GNL3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity GNL3 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name GNL3 E2IG3 NS
Accession No. Q9BVP2 Q8CI11 Q811S9
Description G protein nucleolar 3(GNL3) Homo sapiens The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Protein Expression Eye,
Subcellular Localization extracellular space,nucleus,nucleoplasm,nucleolus,membrane,
Protein Function domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,domain:The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.,function:May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,subcellular location:Shuttles between the nucleus and nucleolus.,subunit:May interact with p53/TP53 via its basic domain.,tissue specificity:Increased levels in lung tissue in cancer patients.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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