ITN0949
ITN0949
- Catalog: ITN0949
- Gene/Protein: CHL1 CALL
- Product Description: Immunotag™ CHL1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CHL1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Specificity | CHL1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CHL1 CALL |
| Accession No. | O00533 P70232 |
| Description | cell adhesion molecule L1 like(CHL1) Homo sapiens The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011], |
| Protein Expression | Brain,Plasma, |
| Subcellular Localization | proteinaceous extracellular matrix,plasma membrane,integral component of membrane,dendrite,apical part of cell,extracellular exosome, |
| Protein Function | disease:The deletion of 1 copy of the CHL1 may be responsible for mental defects in patients with 3p- syndrome. 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 and is characterized by multiple congenital anomalies and mental retardation.,domain:The DGEA motif seems to be a recognition site for integrin.,domain:The FIG[AQ]Y motif seems to be an ankyrin recruitment region.,function:Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.,PTM:Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.,PTM:N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc).,PTM:O-glycosylated.,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Soluble forms produced by cleavage/shedding also exist.,subunit:May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3.,tissue specificity:Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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