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ITN1104

ITN1104
  • Gene/Protein: PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778
  • Product Description: Immunotag™ PNKD Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ PNKD Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PNKD
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 140-220
Specificity PNKD Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778
Accession No. Q8N490 Q69ZP3
Description paroxysmal nonkinesigenic dyskinesia(PNKD) Homo sapiens This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Protein Expression Brain,
Subcellular Localization nucleus,mitochondrion,membrane,
Protein Function disease:Defects in PNKD are the cause of dystonia type 8 (DYT8) [MIM:118800]. DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face.,function:Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.,induction:By Hepatitis C virus core protein.,PTM:Isoform 2 is phosphorylated at Ser-121 upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.,subunit:Isoform 2 interacts with the sarcomeric proteins, MRLC2, MYOM1 and ENO3.,tissue specificity:Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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