ITN1196
ITN1196
- Catalog: ITN1196
- Gene/Protein: PTPRK PTPK
- Product Description: Immunotag™ PTPRK Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PTPRK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 180-260 |
| Specificity | PTPRK Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PTPRK PTPK |
| Accession No. | Q15262 P35822 |
| Description | protein tyrosine phosphatase, receptor type K(PTPRK) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Endometrium carcinoma cell line,Foreskin,Liver,Melano |
| Subcellular Localization | photoreceptor outer segment,integral component of plasma membrane,cell-cell junction,adherens junction,cell surface,membrane,integral component of membrane,axon,dendrite,leading edge membrane,neuronal cell body, |
| Protein Function | catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa.,PTM:This protein undergoes proteolytic processing.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 MAM domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 4 fibronectin type-III domains.,tissue specificity:High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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