ITN1435
ITN1435
- Catalog: ITN1435
- Gene/Protein: TAF4B TAF2C2 TAFII105
- Product Description: Immunotag™ TAF4B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TAF4B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TAF4B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TAF4B TAF2C2 TAFII105 |
| Accession No. | Q92750 |
| Description | TATA-box binding protein associated factor 4b(TAF4B) Homo sapiens TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014], |
| Cell Pathway/ Category | Basal transcription factors,Huntington's disease, |
| Protein Expression | Ovarian carcinoma, |
| Subcellular Localization | nucleoplasm,transcription factor TFIID complex,nucleolus,cytoplasm, |
| Protein Function | function:Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B cell-specific transcription.,PTM:Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).,similarity:Belongs to the TAF4 family.,similarity:Contains 1 histone-fold domain.,similarity:Contains 1 TAFH (NHR1) domain.,subcellular location:Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.,subunit:TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.,tissue specificity:Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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