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ITN1444

ITN1444
  • Catalog: ITN1444
  • Gene/Protein: TRPV5 ECAC1
  • Product Description: Immunotag™ TRPV5 Polyclonal Antibody
334.0000
Price in reward points: 334

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Immunotag™ TRPV5 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TRPV5
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity TRPV5 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name TRPV5 ECAC1
Accession No. Q9NQA5 P69744 Q9JIP0
Description transient receptor potential cation channel subfamily V member 5(TRPV5) Homo sapiens This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008],
Protein Expression Colon,
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,apical plasma membrane,
Protein Function function:Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.,PTM:Glycosylated.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 5 ANK repeats.,subcellular location:Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.,subunit:Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.,tissue specificity:Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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