ITN1501
ITN1501
- Catalog: ITN1501
- Gene/Protein: UBE2K HIP2 LIG
- Product Description: Immunotag™ UBE2K Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UBE2K |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBE2K Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UBE2K HIP2 LIG |
| Accession No. | P61086 P61087 |
| Description | ubiquitin conjugating enzyme E2 K(UBE2K) Homo sapiens The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Ubiquitin mediated proteolysis, |
| Protein Expression | Brain,Platelet,Uterus, |
| Subcellular Localization | nucleus,cytoplasm,filopodium tip,extracellular exosome, |
| Protein Function | catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53.,induction:By aggregated low-density lipoprotein.,pathway:Protein modification; protein ubiquitination.,PTM:Sumoylation at Lys-14 impairs catalytic activity.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,similarity:Contains 1 UBA domain.,subunit:Interacts with RNF138/NARF.,tissue specificity:Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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