ITN1684
ITN1684
- Catalog: ITN1684
- Gene/Protein: CIC KIAA0306
- Product Description: Immunotag™ CIC Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CIC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 550-630 |
| Specificity | CIC Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CIC KIAA0306 |
| Accession No. | Q96RK0 Q924A2 |
| Description | capicua transcriptional repressor(CIC) Homo sapiens The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | nucleus,protein complex, |
| Protein Function | function:Transcriptional repressor which may play a role in development of the central nervous system (CNS).,miscellaneous:Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interact with ATXN1 and ATXN1L.,tissue specificity:Expressed in fetal brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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