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ITN1809

ITN1809
  • Catalog: ITN1809
  • Gene/Protein: CREB3L3 CREBH HYST1481
  • Product Description: Immunotag™ CR3L3 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CR3L3 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CR3L3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity CR3L3 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CREB3L3 CREBH HYST1481
Accession No. Q68CJ9 Q91XE9 Q5FVM5
Description cAMP responsive element binding protein 3 like 3(CREB3L3) Homo sapiens This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
Cell Pathway/ Category Melanogenesis,Huntington's disease,Prostate cancer,
Protein Expression Brain,Epithelium,Ileal mucosa,
Subcellular Localization nucleus,endoplasmic reticulum,endoplasmic reticulum membrane,membrane,integral component of membrane,
Protein Function function:Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with atf6. Interacts with atf6.,tissue specificity:Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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