ITN1836
ITN1836
- Catalog: ITN1836
- Gene/Protein: POR CYPOR
- Product Description: Immunotag™ NCPR Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NCPR |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | NCPR Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | POR CYPOR |
| Accession No. | P16435 P37040 P00388 |
| Description | cytochrome p450 oxidoreductase(POR) Homo sapiens This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008], |
| Protein Expression | Aorta endothelial cell,Liver,Lung,Small intestine, |
| Subcellular Localization | mitochondrion,endoplasmic reticulum membrane,membrane,integral component of membrane,intracellular membrane-bounded organelle, |
| Protein Function | catalytic activity:NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.,cofactor:FAD.,cofactor:FMN.,disease:Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].,disease:Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.,function:This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,similarity:In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,subcellular location:Anchored to the ER membrane by its N-terminal hydrophobic region., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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