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ITN1879

ITN1879
  • Catalog: ITN1879
  • Gene/Protein: PRKG1 PRKG1B PRKGR1A PRKGR1B
  • Product Description: Immunotag™ KGP1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ KGP1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein KGP1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity KGP1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PRKG1 PRKG1B PRKGR1A PRKGR1B
Accession No. Q13976 P0C605
Description protein kinase, cGMP-dependent, type I(PRKG1) Homo sapiens Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin
Cell Pathway/ Category Vascular smooth muscle contraction,Gap junction,Long-term depression,Olfactory transduction,
Protein Expression Glandular pool- thyroid,
Subcellular Localization cytoplasm,Golgi apparatus,cytosol,plasma membrane,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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